7/31/2023 0 Comments Pc diabetes pilot![]() Family-based studies clearly show that genetic factors play an important role in the susceptibility to T2D. They are related disorders, since obesity is a strong risk factor for T2D, and both conditions are strongly hereditary. Obesity and T2D are complex genetic disorders caused by a combination of genetic, epigenetic and environmental factors. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil. Universidade de São Paulo, Departamento de Genética e Biologia Evolutiva, São Paulo, SP, Brazil. Fernanda Andreza de Pinho Lott Figueiredo ![]() Universidade Federal do Pará, Instituto de Ciências da Saúde, Faculdade de Nutrição, Belém, PA, Brazil. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |